Senior Manufacturing Systems Engineer: BAS/QBAS
Company: Amgen
Location: Holly Springs
Posted on: January 17, 2026
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Job Description:
Join Amgens Mission of Serving Patients At Amgen, if you feel
like youre part of something bigger, its because you are. Our
shared missionto serve patients living with serious illnessesdrives
all that we do. Since 1980, weve helped pioneer the world of
biotech in our fight against the worlds toughest diseases. With our
focus on four therapeutic areas Oncology, Inflammation, General
Medicine, and Rare Disease we reach millions of patients each year.
As a member of the Amgen team, youll help make a lasting impact on
the lives of patients as we research, manufacture, and deliver
innovative medicines to help people live longer, fuller happier
lives. Our award-winning culture is collaborative, innovative, and
science based. If you have a passion for challenges and the
opportunities that lay within them, youll thrive as part of the
Amgen team. Join us and transform the lives of patients while
transforming your career. Be part of Amgen's newest and most
advanced drug substance manufacturing plant. When completed, the
Amgen FleX batch facility will combine the latest in disposable
technologies with traditional stainless steel equipment to allow
for maximum flexibility in operations The FleX Batch facility will
not only feature the best in-class drug substance manufacturing
technologies with embedded industry 4.0 capabilities, but it will
also integrate sustainability innovations to reduce carbon and
waste, as part of Amgen's plan to be a carbon-neutral company by
2027. Senior Manufacturing Systems Engineer: BAS/QBAS What you will
do Lets do this. Lets change the world. As a Senior Manufacturing
Systems Engineer, you will provide automation technical leadership
to a group of automation engineers who are responsible for building
and maintaining various automation systems and platforms that
support the GMP Drug Substance Plant Operations. In this vital role
as a member of the Facilities & Engineering (F&E) Automation
team you will work hand in hand with the capital project team to
deliver robust automation systems to operate the new plant. This
includes sophisticated and challenging system automation
initiatives that require understanding of various automation
platforms, integration between different platforms, analytical
problem-solving techniques, project management, lifecycle
management and Operational Excellence. Maintain the Building
Automation System (BAS)on Siemens Desigo CC. Work with process
subject matter experts (SMEs) to understand key process
requirements and transform them into digital automated solutions.
Collaborate with business partners to understand how utility and
building equipment systems automation can improve workflow and
productivity. Synthesize requirements from clients, customers or
end-users to develop the best automation solutions. Provide clear
documentation for delivered solutions and processes; work closely
with QA partners while supporting computerized systems validation
processes in a GxP environment. Maintain Data Integrity Assessments
with the current Amgen and Industry standards. Maintain detailed
specification and engineering policies and procedures that affect
multiple organizational units. Support commissioning and
qualification efforts including Automation Installation
Verification/Automation Check Out (IV/ACO) Lead and support
functional area projects focused on improving process
equipment/utilities/facilities as well as large/sophisticated
capital projects to integrate new drug substance manufacturing
technologies into the facility. Lead/support technical root cause
analysis, incident investigations, and troubleshooting on utilities
and building automation controls Lead and support new product
introductions (NPI) or new technology introductions by performing
automation engineering assessments, implementing automation system
configuration changes and supporting engineering and process
qualification runs as applicable. Handle Day-to-day Operational
Support including: 24 x 7 Onsite/On Call Operational Support,
Troubleshooting Support to Plant and Mfg. Operations, Utility
systems, Utility and BAS Administration, Preventative and
corrective maintenance, and Automation System spare parts
management Be constantly curious and feed your passion and
interests in groundbreaking technology. Use your given time to look
for new and innovative ways to do business differently, better, and
be more cost efficient. What we expect of you! We are all
different, yet we all use our unique contributions to serve
patients. The automation professional we seek is an engineer with
these qualifications. Basic Qualifications: High School Diploma /
GED and 10 years of Engineering experience OR Associates Degree and
8 years of Engineering experience OR Bachelors Degree and 4 years
of Engineering experience OR Masters Degree and 2 years of
Engineering experience OR Doctorate Degree Preferred
Qualifications: Degree in Electrical Engineering or Computer
Science, Chemical Engineering or Biotech Engineering. Direct
knowledge of BAS design, experience in building control engineering
and troubleshooting with GMP biopharmaceutical production facility
and utility equipment/systems automation and integrating various
OEM automation software. Extensive understanding and background in
programming, design, installation and lifecycle management of
building automation controls, PLC and field device/instrumentation
technologies. Experience with Siemens Building Automation system,
Rockwell industrial automation hardware and systems, ability to
perform sophisticated troubleshooting activities with Amgen DTI,
System Integration using OPC, Foundation Fieldbus, Profibus, and
DeviceNet technologies. Ability to interpret and apply GAMPs and
GMPs and familiarity with documentation in a highly regulated
environment with requirements such as 21 CFR Part 11, ASTM 2500,
S88, and S95. Experience in Capital Project Lifecycle Management:
Conceptual Design, Scope and cost estimate development, business
case development, detailed design, engineering and validation
documentation and project implementation. Experience with
continuous improvements resulting in enhanced safety, system
reliability, and productivity (e.g., cycle times, and reduced plant
utilities usage etc.) The ideal individual must be a self-directed
excellent teammate ready to mentor and develop engineering staff
and embrace a team-based culture that relies on collaboration for
effective decision-making. Strong leadership, technical writing,
and communication/presentation skills. What you can expect of us As
we work to develop treatments that take care of others, we also
work to care for your professional and personal growth and
well-being. From our competitive benefits to our collaborative
culture, well support your journey every step of the way. In
addition to the base salary, Amgen offers competitive and
comprehensive Total Rewards Plans that are aligned with local
industry standards. Apply now and make a lasting impact with the
Amgen team! careers.amgen.com As an organization dedicated to
improving the quality of life for people around the world, Amgen
fosters an inclusive environment of diverse, ethical, committed and
highly accomplished people who respect each other and live the
Amgen values to continue advancing science to serve patients.
Together, we compete in the fight against serious disease. Amgen is
an Equal Opportunity employer and will consider all qualified
applicants for employment without regard to race, color, religion,
sex, sexual orientation, gender identity, national origin,
protected veteran status, disability status, or any other basis
protected by applicable law. We will ensure that individuals with
disabilities are provided reasonable accommodation to participate
in the job application or interview process, to perform essential
job functions, and to receive other benefits and privileges of
employment. Please contact us to request accommodation.
Keywords: Amgen, High Point , Senior Manufacturing Systems Engineer: BAS/QBAS, Engineering , Holly Springs, North Carolina
